Not medical advice. 5-Amino-1MQ is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
5-Amino-1MQ is a selective NNMT inhibitor small molecule that preserves intracellular NAD+ and SAM pools, reduces adipocyte hypertrophy, and improves grip strength in diet-induced obesity models.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
5-Amino-1MQ is a selective NNMT inhibitor that preserves intracellular NAD+ and SAM pools by blocking nicotinamide methylation in adipose tissue.
Peer-reviewed literature typically discusses 5-Amino-1MQ in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Researchers study these compounds for mitochondrial function, nutrient sensing, and cellular energy stress responses -often in ageing or metabolic disease models.
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Storage requirements: Store in cool, dry place. Shelf-stable at room temperature. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 50–100 mg oral daily · Once daily, typically morning administration · Rat PK data: Cmax 2252 ng/mL (oral), AUC₀₋∞ 14431 h·ng/mL (oral), t½ 3.80 h (IV) / 6.90 h (oral), oral bioavailability F% = 38.4%. High water solubility (>100 mg/mL) facilitates renal elimination. Biological effects on metabolism persist beyond plasma clearance, suggesting tissue retention or active metabolite formation. No human PK data published.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
In the literature 5-Amino-1MQ is used as a selective NNMT inhibitor tool compound to study fat-cell metabolism, NAD+ and SAM biology, and diet-induced obesity. Preclinical mouse studies have looked at whether blocking NNMT shrinks adipocytes, lowers body weight, and improves glucose handling. It is supplied here for laboratory research only and is not for human use.
No - it is a small molecule (5-amino-1-methylquinolinium) not a peptide. It is included in the research metabolic toolkit because it targets an enzyme pathway (NNMT) that affects the same NAD+ and SAM pools that peptide-based metabolic research often tries to influence.
NNMT uses nicotinamide as its substrate to produce 1-methylnicotinamide. Every nicotinamide molecule that gets methylated is one that can no longer be recycled into NAD+. When NNMT is overactive (as in obese adipose tissue), it drains the nicotinamide pool and limits NAD+ biosynthesis. Blocking NNMT with 5-Amino-1MQ preserves nicotinamide for NAD+ regeneration.
The data is preclinical. In high-fat-diet mouse models, 5-Amino-1MQ has been reported to reduce body weight, white adipose mass, and adipocyte size, and a 2024 study found NNMT inhibition improved glucose tolerance and fatty-liver markers in diet-induced obese mice without reducing food intake - pointing to an adipose/energy-expenditure mechanism rather than appetite suppression. No human clinical efficacy has been established.
Rat pharmacokinetic studies describe roughly 38% oral bioavailability with a plasma half-life around 3.8 h IV and 6.9 h oral, and very high water solubility (>100 mg/mL). That oral profile is unusual for a metabolic compound and is one reason it is studied with once-daily oral protocols. No human PK data has been published.
Both are studied for metabolism, but they are structurally and mechanistically different. 5-Amino-1MQ is a small-molecule NNMT inhibitor that preserves NAD+/SAM pools, while MOTS-c is a 16-amino-acid mitochondrial-derived peptide that activates AMPK as an "exercise mimetic". One is an enzyme inhibitor taken orally; the other is an injectable signalling peptide.
Unlike most peptides on this site, 5-Amino-1MQ is a stable small molecule that does not require freezing. Store it in a cool, dry place at room temperature; it is shelf-stable in that state.
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Primary literature and registries for 5-Amino-1MQ, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
Access concentration, batch info, variants, and current pricing on our shop.
Also known as: 5-Amino-1MQ, 5-Amino-1-Methylquinolinium, 5-AMQ, NNMT Inhibitor, 5-Amino-1-Methylquinolinium Iodide, NNMT-I