Not medical advice. Epitalon is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
Epitalon (also spelled Epithalon) is a four-amino-acid tetrapeptide that reactivates telomerase expression in human somatic cells, extending replicative lifespan beyond the Hayflick limit in classic fibroblast aging experiments.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
Epitalon (AEDG) is a synthetic tetrapeptide telomerase activator that upregulates hTERT expression to elongate telomeres in human somatic cells.
Peer-reviewed literature typically discusses Epitalon in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Researchers study these compounds for mitochondrial function, nutrient sensing, and cellular energy stress responses -often in ageing or metabolic disease models.
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 5–10 mg subcutaneous injection · Once daily for 10–20 consecutive days, repeated every 4–6 months · Formal human pharmacokinetic parameters (t½, Vd, bioavailability) have not been published. As a tetrapeptide (MW 390.35 Da), Epitalon is subject to rapid peptidase hydrolysis releasing constituent amino acids. Subcutaneous and intraperitoneal routes are standard in published animal protocols. BBB penetration has been demonstrated in animal models. Oral bioavailability is not characterized.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Epitalon (AEDG) is studied as a telomerase-activating bioregulator peptide and a tool compound in telomere biology, cellular-senescence, and longevity research. Cell-culture work has examined hTERT reactivation and telomere elongation, while animal studies have looked at pineal melatonin output and lifespan endpoints. It is supplied here for laboratory research only and is not for human use.
Yes - the two spellings refer to the same tetrapeptide (Ala-Glu-Asp-Gly). "Epitalon" and "Epithalon" are interchangeable transliterations of the Russian name. You will also see "Epithalone" and "AEDG peptide" in the literature, all referring to the same compound.
Epitalon binds specific DNA motifs (the ATTTC element) in the hTERT promoter and forms complexes with histone proteins, which favours transcription of hTERT - the catalytic subunit of telomerase. Re-expressing hTERT in somatic cells that had silenced it lets telomeres lengthen rather than shorten with each division. This is a promoter-level mechanism rather than indirect signalling, which is unusual for such a small peptide.
That is a longevity research question that has not been definitively answered. The cell-culture telomere-elongation data is clear, and there are animal studies showing increased maximum lifespan. Human longevity data is limited to small studies and the related pineal extract epithalamin, not the synthetic AEDG peptide. It remains a research compound, not a validated longevity therapy.
Published Russian research protocols describe a pulsed pattern - around 5-10 mg subcutaneously once daily for 10-20 consecutive days, followed by a 4-6 month rest period before the next cycle. This pulse-then-rest design mirrors the original animal study schedules. These figures are descriptive of the literature and are not a recommendation; the material is for laboratory research only.
Both are studied in aging research but work on opposite ends of the problem. Epitalon is a telomerase activator that aims to slow telomere-driven senescence by keeping cells dividing, whereas FOXO4-DRI is a senolytic that selectively kills cells that have already become senescent. One delays the onset of senescence; the other clears existing "zombie" cells.
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The tetrapeptide is small and simple, so it tolerates standard peptide handling well within the normal usage window.
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Other compounds researchers often read about alongside Epitalon.
Primary literature and registries for Epitalon, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: Epitalon, Epithalon, Epithalone, AEDG Peptide, Ala-Glu-Asp-Gly, Epitalon Tetrapeptide, Khavinson Peptide, Epithalamin Synthetic Analog