Not medical advice. HCG is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
Human chorionic gonadotropin (hCG) is a 237-amino-acid heterodimeric glycoprotein that activates the LH/CG receptor, used in published research as a luteinizing hormone surrogate for gonadal steroidogenesis and fertility studies.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
HCG glycoprotein hormone (α/β heterodimer, 37.9 kDa) activates LHCGR receptor via PKA/PKC/Smad2 cascades for gonadal steroidogenesis and fertility support.
Peer-reviewed literature typically discusses HCG in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Compounds in this family are frequently studied in models of tissue injury, wound closure, and how cells reorganise after damage. Research looks at cell movement, blood-vessel support, and inflammatory balance -not at replacing medical care.
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 250-10,000 IU depending on indication · Variable: single dose (IVF trigger), 2-3 times weekly (hypogonadism), as directed · Terminal t½ ~45 hours (substantially longer than LH). Apparent CL/F ~0.5 L/h; Vz/F ~30 L. SC bioavailability reduced in obese individuals. 1 IU = 1.68 μg pure peptide. Renally cleared; urinary hCG basis of pregnancy tests. Eight carbohydrate chains comprise 30% of molecular weight.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Human chorionic gonadotropin is a heterodimeric glycoprotein hormone produced by the placenta. It works by binding the LH/CG receptor (LHCGR) shared with luteinizing hormone, switching on the PKA/PKC steroidogenic cascade. On Leydig cells that drives testosterone biosynthesis; on ovarian granulosa cells it triggers final oocyte maturation, which is why it functions as an LH surrogate in reproductive research.
Like all gonadotropins, hCG is calibrated against an international biological potency standard rather than by mass, because glycosylation pattern can change the mass-to-bioactivity ratio. One IU corresponds to approximately 1.68 μg of pure peptide. Published research protocols preserve the IU convention because it tracks biological activity directly rather than weight.
hCG and LH share the same alpha subunit and act on the same receptor (LHCGR). The unique, heavily glycosylated beta-subunit tail gives hCG a much longer circulating half-life — on the order of ~24–36 hours versus roughly 30 minutes for LH — which is why hCG is the preferred research tool for sustained receptor activation. In Leydig-cell studies, plasma testosterone rises within an hour of an hCG bolus even though receptor binding sites subsequently down-regulate.
Pharmacokinetic work reports a terminal half-life substantially longer than LH, with apparent clearance around 0.5 L/h after subcutaneous administration. In Leydig-cell physiology studies, a single hCG injection produces a rapid plasma testosterone rise within the first hours, followed by receptor down-regulation over the following days. These are descriptive published-research findings, not a protocol — hCG is supplied for laboratory research only.
In assisted-reproduction research hCG is used as the "trigger" that mimics the natural mid-cycle LH surge, prompting final oocyte maturation before egg retrieval. In male reproductive models it is studied as an LH stand-in to drive endogenous testosterone production. Both uses exploit the same LHCGR agonism; New-U supplies hCG strictly for in-vitro and preclinical research, not for human fertility use.
They act at opposite ends of the same axis. hCG acts at the bottom, directly on the gonad via the LH/CG receptor, mimicking the LH surge. Kisspeptin acts at the very top, on hypothalamic GnRH neurons, switching on the whole cascade more physiologically. Researchers pick hCG when they want direct gonadal stimulation and kisspeptin when they want to study upstream, natural control of LH/FSH release.
Keep the lyophilised glycoprotein at −20 °C in the freezer. After reconstitution with bacteriostatic water, refrigerate at 2–8 °C and protect from light. Avoid vigorous shaking and repeated freeze-thaw cycles, which can damage the heavily glycosylated structure and reduce bioactivity. This is laboratory handling guidance only.
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Other compounds researchers often read about alongside HCG.
Primary literature and registries for HCG, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: HCG, Human Chorionic Gonadotropin, hCG, Chorionic Gonadotropin, Pregnyl, Novarel, Ovidrel, Choriogonadotropin Alfa, LH Surrogate