Buy Semax
Also known as ACTH(4-10)-Pro-Gly-Pro, Semax Heptapeptide, MEHFPGP, ACTH 4-10 Analogue, Semax Acetate, N-Acetyl Semax, Семакс
Semax is a synthetic ACTH(4-10) heptapeptide nootropic that upregulates BDNF/TrkB signaling and modulates dopaminergic and serotonergic neurotransmission.
Why buy Semax from New-U Research Compounds
- >99% HPLC purity — every batch independently verified by Janoshik Analytics & Freedom Diagnostics, with a batch-linked Certificate of Analysis
- 10-vial research packs — a full research supply per compound, not single vials
- Direct-from-source pricing — no middleman markup
- 6–14-day worldwide delivery — direct from source, discreet, cold-chain worldwide
- Free shipping over $300 — card and cryptocurrency accepted
- Trusted by 10,000+ researchers worldwide
What is Semax?
Semax is a Russian nootropic heptapeptide derived from ACTH that rapidly elevates BDNF and TrkB expression in the hippocampus, producing 20-24 hour cognitive and neuroprotective effects from a single intranasal dose.
Semax rapidly upregulates BDNF and TrkB in the hippocampus, tunes serotonin and dopamine neurotransmission, and activates enkephalin-dependent signalling - all from a brief plasma exposure.
Semax at a glance
| Sequence | MEHFPGP |
|---|---|
| Molecular weight | 813.92 Da |
| Purity | >99% HPLC |
| Form | Lyophilised powder |
| Category | Cognitive / Neuro |
| Storage | Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. |
Semax pricing
| Research pack | Per vial | Price |
|---|---|---|
| 10 vials | 5mg | $80 |
| 10 vials | 10mg | $120 |
All packs are >99% HPLC research-grade material. Free shipping on orders over $300.
Frequently asked questions
Where can I buy Semax?
Semax is available directly from New-U Research Compounds at https://new-u.io/peptide/semax. Every batch is independently third-party tested by Janoshik Analytics and Freedom Diagnostics to >99% HPLC purity, supplied as lyophilised research-grade material, and shipped direct from source worldwide (approximately 6–14 business days).
How much does Semax cost?
Semax starts at $80 for a 10-vial research pack (5mg per vial) at New-U Research Compounds, with 2 pack sizes available. Orders over $300 ship free.
Is New-U Semax third-party tested?
Yes. Every Semax batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC area normalisation.
How fast does Semax ship, and do you ship internationally?
Semax ships direct from source, discreetly worldwide with cold-chain handling where required. Delivery is approximately 6–14 business days worldwide. Shipping is free on orders over $300. Card and cryptocurrency payments are accepted.
Is it legal to buy Semax?
In the United States, Semax is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
What is Semax used for in research?
Semax is a synthetic ACTH(4-10) heptapeptide nootropic that upregulates BDNF/TrkB signaling and modulates dopaminergic and serotonergic neurotransmission. New-U supplies Semax as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the Semax research profile. Not for human use.
What is the typical Semax research dosage?
Reconstitution volumes and dosing reported in the literature for Semax are described in research-model terms only. New-U Research Compounds supplies Semax strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.
What do I use to reconstitute Semax?
Lyophilised Semax is reconstituted with bacteriostatic water — sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide. Supplied for laboratory research only — not for human use.
Can I buy Semax online and how fast does it ship?
Yes. Semax can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $300.
Can I buy Semax in bulk?
Semax ships in 10-vial research packs as standard, in 2 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $300. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.
What should I look for when choosing where to buy Semax?
For research-grade Semax, verify four things: (1) independent third-party purity testing with a batch-linked Certificate of Analysis — New-U uses Janoshik Analytics and Freedom Diagnostics at >99% HPLC; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/semax.
What is Semax and how does it work?
Semax is a synthetic seven-amino-acid (heptapeptide) analogue of ACTH(4-10) with a Pro-Gly-Pro tail, studied as a nootropic and neuroprotective research compound. In animal models it rapidly raises BDNF and TrkB signalling in the hippocampus and modulates serotonin and dopamine neurotransmission, which is the mechanistic basis for the cognition and mood endpoints reported in the literature. New-U supplies it for laboratory research only.
What does the Semax research actually show?
The most cited preclinical findings are neurotrophic and monoaminergic. A single dose of Semax increased hippocampal BDNF protein and TrkB phosphorylation in rats (Dolotov et al., 2006), and Semax raised striatal extracellular 5-HIAA to roughly 180% in a 1-4 hour window in rodents (Eremin et al., 2005). Most positive cognitive and stroke-recovery data come from Russian clinical and animal studies; these are research findings, not a promise of any effect in humans.
What is the half-life of Semax and how long does it last?
Published pharmacology describes a short plasma half-life (on the order of minutes) but a much longer functional window, because the BDNF/TrkB upregulation it triggers persists after the peptide itself has cleared. This is why the literature often separates Semax's circulating half-life from its downstream effect duration. We describe these figures descriptively from the research and make no dosing recommendation.
Is Semax legal, and is it FDA-approved?
Semax is not FDA-approved in the United States and is sold strictly as a research chemical for laboratory use - it is not approved for human consumption here. It is, however, a registered/approved medicine in Russia (and reportedly Ukraine) for indications such as ischemic stroke and cognitive disorders. Legal status varies by jurisdiction, so confirm your local rules before purchasing.
Why is intranasal used instead of injection in Semax research?
Intranasal delivery uses the olfactory pathway to reach the brain quickly, which suits a peptide with a short plasma half-life that needs to act centrally. Russian clinical formulations are typically nasal drops; subcutaneous administration also appears in the literature. The route choice is about getting peptide to brain tissue efficiently, not a recommendation on how anyone should dose it.
Does Semax have ACTH-like effects on cortisol?
No - the ACTH(4-10) fragment carries the neurotropic activity of ACTH but lacks the adrenal-stimulating portion of the full hormone, so it does not act as a meaningful cortisol stimulus. That separation of neurotrophic activity from hormonal activity was a deliberate design choice and is one reason Semax is studied as a cognition tool rather than a hormone.
How is Semax different from Selank, and from Noopept?
Semax and Selank are both Russian Pro-Gly-Pro heptapeptides given intranasally, but from different parents: Semax is ACTH(4-10)-derived and emphasises cognition and neuroprotection, while Selank is tuftsin-derived and emphasises anxiolysis - they are sometimes studied together. Noopept is an unrelated small-molecule (a dipeptide-like racetam derivative), not a true peptide, so it is a different chemical class entirely despite the overlapping nootropic research interest.
How should Semax be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail makes Semax noticeably more stable than ACTH(4-10) alone, but standard peptide handling still applies - avoid repeated freeze-thaw cycles.
Research references
Independent literature and reference sources for Semax. Provided for scientific context — New-U Research Compounds supplies research-use-only material.
- Semax — Wikipedia
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research.
- Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochemical Research.
Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full Semax research profile or the Semax research guide.